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Hepatitis C

memorize.ai (lvl 286)

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Section 1

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What factors might promote dz progression or severity?

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Last updated

6 years ago

Date created

Mar 14, 2020

Cards (12)

Section 1

(12 cards)

What factors might promote dz progression or severity?

Front

-increased alcohol intake -age > 40 -HIV coinfection

Back

How do we treat autoimmune hep?

Front

induction with steroids maintenance azathioprine with steroids (can D/C pred when azathioprine has had some time to take effect)

Back

When is liver transplant the therapy of choice, and what might occur in an infected patient who gets one?

Front

fulminant hepatic failure (and other end stage liver dzs) -recurrence of viral infection is common

Back

How does HepC commonly present?

Front

acute is not very common; most people are asymptomatic and don't know they have it until tested for it

Back

Which treatment is considered the "holy grail" for HepC tx but is quite expensive?

Front

glecaprevir/pibrentasvir --8 weeks with food

Back

What is the treatment goal for HepC and when is this not the case?

Front

goal is to CURE patients with chronic HepC; except: those with short life expectancies that cannot be remediated by treating HepC, transplant, or other therapies

Back

When is a liver biopsy important and necessary for diagnosing hepatitis?

Front

in the case of autoimmune Hep

Back

How is HepC commonly spread?

Front

percutanious or permucosally (four times more common among IV drug users than HIV)

Back

When do we care about HepC genotypes?

Front

if the pt doesn't qualify for initial tx

Back

How does treatment length DIFFER in pts who do have cirrhosis?

Front

tx for pts with cirrhosis will be for AT LEAST 12 weeks, possibly longer (can still treat tho which is big)

Back

Which genotype is most common in the US and most difficult to treat?

Front

genotype 1

Back

What are the classes of direct-acting antivirals and how can we tell them apart?

Front

NS3/4 Protease inhibs (-previr) -- protease = previr NS5A Inhibs (-asvir) --A = asvir NS5B Polymerase inhibs (-buvir) --B = busvir

Back