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Abbas Chapter 3

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Section 1

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What kind of receptors chemokine receptors are

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6 years ago

Date created

Mar 1, 2020

Cards (18)

Section 1

(18 cards)

What kind of receptors chemokine receptors are

Front

Seven transmembrane GTP binding G protein associated, activates Phospholipase C and then protein kinase C

Back

How T cells and dendritic cells migrate to T cell areas in LNs

Front

Express CCR7 attracted to CCL19 and CCL21

Back

Hematopoietic stem cell markers

Front

CD34 and c-kit

Back

Chemokine coreceptors for HIV

Front

CCR5 CXCR4**

Back

How antigens are presented in LNs

Front

1. Viruses and large antigens are eaten by macrophages and presented to cortical B cells in sinuses. 2. Small soluble antigens are pinocytosed by dendritic cells in FRCs. 3. Tissue dendritic cells transport antigens from periphery through afferent lymphatics.

Back

LAD 1 deficiency

Front

AR deficiency in CD18 hence lack of LFA-1 and Mac-1 integrins

Back

Survival cytokine for T cell

Front

IL-7

Back

Chemokines produced in tissues bind to ___ _ _____ on endothelial cells.

Front

Chemokines produced in tissues bind to heparin sulfate proteoglycans on endothelial cells. --> high concentration of chemokines at site of infection; --> chemokine receptor binding leads to enhanced integrin affinity on leukocytes.

Back

Survival cytokine for B cell

Front

BAFf

Back

Marker for activated T lymphocyte

Front

CD25 (part of IL2 receptor)

Back

LAD 2 deficiency mechanism

Front

Lack of E selectin and P selectin ligands (sialyl Lewis X)

Back

NAME Selectins and ligands

Front

P Selectin- on Endotheliym, bind to Sialyl Lewis X (sLex) E Selectin- On Endothelium, bind to sLex L Selectin - on Leukocytes, bind to scialomucin on HEV peripheral node addressin (PNAd)

Back

Which is the notable CD molecule expressed on leukocytes and endothelial cells- that is a key player in paracellular transmigration of leukocytes through the endothelium?

Front

CD31 Allows for transient and reversible disruption of VE cadherin complex

Back

How B cells migrate to B cell areas in LNs

Front

Express CXCR5 attracted to CXCL13 produced by FDCs

Back

Chemokines for neutrophils and macrophages

Front

CXCR1 and CXCR2 for neutrophils binds to CXCL8. CCR2 on monocytes binds to CCL2

Back

NAME Integrins and ligands

Front

LFA1 (CD11aCD18)- Ligand ICAM1 VLA4 (CD49dCD29)- VCAM1 MaC1 (CD11b CD18 OR CR3)- ICAM1

Back

Integrin that's also important for T-cell interaction with APCs

Front

LFA-1 to ICAM-1

Back

Integrin that's also a complement receptor

Front

Mac-1 (also known as CR3) enhances phagocytosis by monocytes by binding inactivated c3B

Back

Abbas Chapter 3

Preview this deck

What kind of receptors chemokine receptors are

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Cards (18)

What kind of receptors chemokine receptors are

Seven transmembrane GTP binding G protein associated, activates Phospholipase C and then protein kinase C

How T cells and dendritic cells migrate to T cell areas in LNs

Express CCR7 attracted to CCL19 and CCL21

Hematopoietic stem cell markers

CD34 and c-kit

Chemokine coreceptors for HIV

CCR5 CXCR4**

How antigens are presented in LNs

1. Viruses and large antigens are eaten by macrophages and presented to cortical B cells in sinuses. 2. Small soluble antigens are pinocytosed by dendritic cells in FRCs. 3. Tissue dendritic cells transport antigens from periphery through afferent lymphatics.

LAD 1 deficiency

AR deficiency in CD18 hence lack of LFA-1 and Mac-1 integrins

Survival cytokine for T cell

IL-7

Chemokines produced in tissues bind to _______ _______ _______ on endothelial cells.

Chemokines produced in tissues bind to heparin sulfate proteoglycans on endothelial cells. --> high concentration of chemokines at site of infection; --> chemokine receptor binding leads to enhanced integrin affinity on leukocytes.

Survival cytokine for B cell

BAFf

Marker for activated T lymphocyte

CD25 (part of IL2 receptor)

LAD 2 deficiency mechanism

Lack of E selectin and P selectin ligands (sialyl Lewis X)

NAME Selectins and ligands

P Selectin- on Endotheliym, bind to Sialyl Lewis X (sLex) E Selectin- On Endothelium, bind to sLex L Selectin - on Leukocytes, bind to scialomucin on HEV peripheral node addressin (PNAd)

Which is the notable CD molecule expressed on leukocytes and endothelial cells- that is a key player in paracellular transmigration of leukocytes through the endothelium?

CD31 Allows for transient and reversible disruption of VE cadherin complex

How B cells migrate to B cell areas in LNs

Express CXCR5 attracted to CXCL13 produced by FDCs

Chemokines for neutrophils and macrophages

CXCR1 and CXCR2 for neutrophils binds to CXCL8. CCR2 on monocytes binds to CCL2

NAME Integrins and ligands

LFA1 (CD11aCD18)- Ligand ICAM1 VLA4 (CD49dCD29)- VCAM1 MaC1 (CD11b CD18 OR CR3)- ICAM1

Integrin that's also important for T-cell interaction with APCs

LFA-1 to ICAM-1

Integrin that's also a complement receptor

Mac-1 (also known as CR3) enhances phagocytosis by monocytes by binding inactivated c3B

Chemokines produced in tissues bind to ___ _ _____ on endothelial cells.