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memorize.aimemorize.ai (lvl 286)
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23 cards
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Section 1

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1. Competitively inhibits Xanthine oxidase 2. purines lost as Xanthine and Hypoxanthine (never cinverted to uric acid) (can also block purine synthesis)

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Last updated

6 years ago

Date created

Mar 1, 2020

Cards (23)

Section 1

(23 cards)

1. Competitively inhibits Xanthine oxidase 2. purines lost as Xanthine and Hypoxanthine (never cinverted to uric acid) (can also block purine synthesis)

Front

Allopurinol MOA

Back

Non-competitively inhibits Xanthine oxidase by preventing molecules from going into the channel to the active site

Front

Febuxostat MOA

Back

Sulfoxide reduction product of Sulfinpyrazone

Front

What is this?

Back

Glycine conjugate

Front

The _______ is the most potent form of Probenecid

Back

Febuxostat

Front

What is this?

Back

Rasburicase

Front

______ is a medication that helps clear uric acid from the blood by enhancing uricase activity

Back

Allopurinol

Front

What is this?

Back

Xanthine oxidase (formation of UA) Uricase (breakdown of UA)

Front

Which enzymes are targeted by Gout drugs?

Back

yes

Front

Is sulfinpyrazone a prodrug?

Back

Sulfinpyrazone

Front

What is this?

Back

Probenicid

Front

What is this?

Back

Colchicine

Front

What is this?

Back

Uric acid

Front

What is this?

Back

carboxilic acid inhibits URTA1

Front

Probenecid MOA

Back

Alloxanthine

Front

What is the active metabolite of Allopurinol?

Back

Yes and no. Both the parent and metabolite are active.

Front

Is probenecid a prodrug?

Back

Aromatic hydroxylation product of Sulfinpyrazone (Parahydroxy metabolite)

Front

What is this?

Back

Probenecid Glycine Conjugate (metabolite)

Front

What is this?

Back

1. When metabolized by aromatic hydroxylation (parahydroxy metabolite): URTA1 inhibitor 2. When metabolized by sulfoxide reduction: COX inhibition in platelets

Front

Sulfinpyrazone MOA

Back

nope

Front

Is Febuxostat a prodrug?

Back

Alloxanthine

Front

What is this?

Back

1. inhibits microtubule formation 2. inhibit mitosis or 1. inhibit lactic acid production 2. increases pH* and solubalizes uric acid

Front

Colchicine MOA

Back

Yes and No. Both the parent and metabolite are active. (The metabolite has a longer half life so it is more active than the parent)

Front

Is Allopurinol a prodrug?

Back