Local Signaling. A secreting cell acts on nearby target cells by discharging molecules of a local regulator into the extracellular fluid. Ex: Growth Factors.
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reception
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The target cell's detection of a signal molecule coming from outside the cell.
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signal transduction pathway
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The process by which a signal on a cell's surface is converted into a specific cellular response.
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G-protein-linked receptor
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A plasma membrane receptor that works with the help of a G-protein.
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second messengers
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Small, non-protein water soluble molecules or ions that send messages throughout the cells by diffusion.
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protein kinase
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The enzyme that transfers phosphate groups from ATP to protein.
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response
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The transduced signal finally triggers a specific cellular response.
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ligand-gated ion channel
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Type of membrane receptor that has a region that can act as a "gate" when the receptor changes shape.
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hormones
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Circulating chemical signals that are formed in specialized cells, travel in body fluids, and act on specific target cells.
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endocrine
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Long distance signaling. Signals sent into blood stream, message may reach all body cells.
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receptor tyrosine kinase
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A receptor with enzymatic activity that can trigger more than one signal transduction pathway at once, helping the cell regulate and coordinate many aspects of cell growth and reproduction.
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cyclic AMP
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cAMP (a second messenger) activates another protein, usually protein kinase A, leading to cellular response.
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ligand
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A molecule that specifically binds to another molecule, often a larger one.
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synaptic
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Local Signaling. Occurs in animal nervous system, nerve releases neurotransmitter molecules into synapse, stimulating target cell.
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transduction
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The binding of the signal molecule changes the receptor protein in some way.