Hydrophobic (nonpolar) molecules, such as hydrocarbons, carbon dioxide, and oxygen, can dissolve in the lipid bilayer of the membrane and cross it with ease and without aid.
The direct passage of ions and polar molecules are impeded by the hydrophobic core; polar molecules such as glucose and other sugars, as well as water, pass through only slowly.
Charged atoms and molecules have even more difficulty; proteins built into the membrane play roles in regulating transport of such things, ultimately making the membrane permeable to specific ions and a variety of polar molecules