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Phenothiazines PLUS...

memorize.ai (lvl 286)

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Section 1

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Iloperidone #hella Oooooss

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Last updated

6 years ago

Date created

Mar 1, 2020

Cards (30)

Section 1

(30 cards)

Iloperidone #hella Oooooss

Front

Use: tx of + & - schizo Serotonin-dopamine antagonist

Back

Thiothixene

Front

Schizophrenia Isosteric

Back

Pimozide

Front

Tourette Syndrome

Back

Palperidone palmitate

Front

14C prodrug of risperidone Admin IM q 4 wks

Back

Ziprasidone

Front

Use: tx of + & - schizo & BPD Serotonin-dopamine antagonist with food

Back

Fluphenazine Enanthate

Front

7 Cs PRO-DRUG half life: 163-232 hrs DF: oral, IM, subQ, oral (?) Admin Q2-4 weeks

Back

Molindone

Front

Schizophrenia, antipsychotic metab: ALOT, 26 metabs contains morpholino + indole

Back

Droperidol

Front

Reduces incidence of N/V associated with surgical + diagnoistic procedures Prevents N/V during chemoTX

Back

Fluphenazine decanoate

Front

10C in USA PRO-DRUG Df: IM, subQ, oral(?) admin 2-4 weeks

Back

Haloperidol

Front

a butyrophenone that was used as an antischizophrenic drug Schizophrenia MOA: low: D2 inverse agonist, alpha-1 antag , high: serotonin antagonist half life: 12-38 hours vs 3 weeks (IM) DF: oral, IM metab: alcohol gluC, Oxidative Dealkylation-where?

Back

Loxapine Succinate

Front

Use: + schizo ONLY Looks like clozapine a litte

Back

Trifluoperazine

Front

piperazine Schizophrenia, non-psychotic anxiety (NOT DOC)

Back

Risperidone

Front

Use: + & - schizo, Bipolar-1 Disorder in 10-18 yo Serotonin-dopamine antagonist PO, IM q 2 wks

Back

Olanzapine (thiophene)

Front

Use: tx of + & - schizo BZ structure FEWER Parkinson symptoms LESS sedation

Back

Asenapine (not in USA)

Front

Atypical (2nd gen) Antipsychotic Based off mirtazapine & Mianserin Use: Acute Manic, related to schizo, BPD Serotonin-dopamine antagonist increased affinity at 5HT, Dopamine, alpha 1 & alpha 2 receptors DF: Sublingual tab

Back

Prochlorperazine

Front

piperazine Schizophrenia, non-psychotic anxiety (NOT DOC)

Back

Promethazine

Front

only 2 Cs, so weak Anti-emetic 1/10 activity of chlorpromazine H1 blocking activity

Back

Perphenazine

Front

Piperazineethanol Schizophrenia

Back

Thioridazine

Front

Only 1 with piperidine Schizophrenia anticholinergic, alpha adrenergic-blocking, dopamine blocking 2 active metabolites sulfoxide: 8X sulfone: 16X

Back

Lithium Citrate

Front

Back

Brexpiprazole

Front

Tx: tx of + & - schizo MOA: D2 partial agonist, 5HT-1A partial agonist, 5HT-2A antagonist not same metab from b4

Back

Chlorpromazine

Front

control N/V avoid heat & light-causes oxidation brown bottle inactive

Back

Phenothiazine

Front

piperazineethanol > piperazine>dimethyl

Back

Clozapine

Front

Se: Agranulocytosis tx of + & - schizo, NOT first line tx

Back

Fluphenazine

Front

Piperazineethanol Schizophrenia half life: 33 hrs

Back

Lurasidone

Front

Use: tx of + & - schizo Serotonin-dopamine antagonist with food

Back

Lithium Carbonate

Front

Back

Quetiapine (check metab oxidation site)

Front

Use: tx of + & - schizo, bipolar-1 Serotonin-dopamine antagonist inactive metabs

Back

Aripiprazole (Abilify)

Front

Tx: tx of + & - schizo MOA: D2 partial agonist, 5HT-1A partial agonist, 5HT-2A antagonist active metabolite (2X bond) #didehydro via oxidation reaction IM, comes as Prodrug

Back

Triflupromazine

Front

control N/V > lipophillic

Back