They are involved in hormone synthesis and breakdown, cholesterol synthesis, vitamin D metabolism, and drug and toxic substance breakdown.
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CYP450s They are involved in hormone synthesis and breakdown, cholesterol synthesis, vitamin D metabolism, and drug and toxic substance breakdown. CYP450s are the major enzymes involved in drug metabolism, which makes this system important in medical practice to ensure proper patient dosing and response based upon an individual's genetic CYP450 makeup.
CYP450s are the primary, but not the only, hepatic enzymes involved in drug metabolism.
There are many CYP450s (at least 18 with possible isoenzymes of each).
CYP450s are found primarily in the liver. They accept a variety of substrates and so are able to metabolize diverse compounds. Each CYP450 can metabolize several different drugs, making the CYP450 family versatile and able to address the wide range of chemical substances encountered by an individual.
Question Difficulty: Level 2