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URN 2 - Neoplasia of Urinary Tract

URN 2 - Neoplasia of Urinary Tract

memorize.aimemorize.ai (lvl 286)
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31 cards
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Section 1

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clear cell RCC

Front

1 / 31

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Last updated

6 years ago

Date created

Mar 1, 2020

Cards (31)

Section 1

(31 cards)

clear cell RCC

Front

renal neoplasia w/ tendency to invade renal vein and reach heart w/o mets

Back

Wilms Tumor (Nephroblastoma) gonadal dysgenesis, early onset nephropathy (diffuse mesangial sclerosis), wilms tumor

Front

which renal neoplasia is assocd w/ Denys-Drash Syndrome? describe DDS

Back

wilms tumor (nephroblastoma)

Front

most common primary renal tumor of childhood (2-5 yrs)

Back

loss of WT-1 on chrom 11 (two hit theory of recessive tumor suppressor genes)

Front

genetics of wilms tumor (nephroblastoma)

Back

renal tubular epithelium

Front

cell origin of renal papillary adenoma

Back

abnormal hormone production results in a variety of syndromes

Front

why is RCC considered a great mimicker

Back

3p25 deletion (VHL)

Front

genetics assoc w/ Clear Cell RCC

Back

Urothelial carcinoma

Front

dx this renal neoplasm w/ papillary "cauliflower" appearance

Back

Angiomyolipoma

Front

Dx of trichrome stain? blue = vessels red = smooth muscle

Back

CVA tenderness, Palpable mass, Hematuria

Front

RCC presentation triad (although not always all presented together)

Back

DCT cuboidal or columnar cells

Front

cell origin of papillary carcinoma

Back

RCC, Wilms Tumor, Urothelial Carcinoma

Front

malignant type kidney neoplasms (3)

Back

Tuberous Sclerosis (TSC1 and TSC2)

Front

Angiomyolipoma often presents w/ _____________ which is due to a loss of function mutation of ___________ and _____________

Back

WAGR, Denys-Drash, Beckwith-Wiedman

Front

3 syndromes assoc w/ Wilms tumor (nephroblastoma)

Back

VHL inactive, HIF-1 hyperactive; growth and angiogenesis

Front

two proteins and their status assoc w/ clear cell RCC; what do these two encourage?

Back

Papillary Carcinoma; Tri-7 and Tri-17; MET protooncogene

Front

RCC subtype assoc w/ trisomies; which ones? which protein affected?

Back

mix of fat, muscle, vessels

Front

describe kidney angiomyolipoma

Back

large eosinophilic cell but benign, mahogany color, central scar, packed w/ mithochondria

Front

describe kidney oncocytoma

Back

very small lesion that can sometimes lead to severe HTN

Front

describe JG cell tumor

Back

Wilms tumor (nephroblastema)

Front

dx this renal neoplasm 1. epithelial component of tubular cells and primitive gloms 2. blastemal component 3. stromal cells

Back

Adenoma, Oncocytoma, Angiomyolipoma, JG cell tumor

Front

benign Kidney Neoplasias (4)

Back

renal oncocytoma

Front

nests of cells, well demarcated, eosinophilic granular cytoplasms w/ central nucleus and prominent nucleolus

Back

Wilms Tumor (Nephroblastoma) Wilms tumor, aniridia (absence of iris), genital anomalies, mental retardation

Front

which renal neoplasia is assocd w/ WAGR syndrome? describe WAGR syndrome

Back

Angiomyolipoma

Front

Dx? 1. mature adipocytes 2. spindle cells and bundles of smooth muscle 3. blood vessels

Back

Wilms Tumor (Nephroblastoma) enlarged organs, hemihypertrophy of extremities, wilms tumor

Front

which renal neoplasia is assoc w/ Beckwith Wiedman Sydrome? describe BWS

Back

PCT epithelium

Front

cell origin of clear cell RCC

Back

6th decade of life

Front

decade of life assoc w/ RCC

Back

renal papillary adenoma

Front

renal neoplasia w/ complex fronds w/ polygonal cells (no clear cells)

Back

large soft mass well demarcated

Front

gross description of wilms tumor (nephroblastoma)

Back

intercalated cells of collecting duct

Front

cell origin of renal oncocytoma

Back

perivascular epithelioid cells

Front

cell origin of angiomyolipoma

Back