the separation of the maternal and paternal sister chromatids randomly to opposite poles
- maternal and paternal sister chromatids of the tetrad orient toward opposite poles randomly during metaphase 1
- the number of possible combinations due to independent assortment is 2^n , where n is the haploid number of species
- for humans n=23 , so there are 2^23 possible combinations of chromosomes each time a cell undergoes meiosis
- 2^23 = 8.4 million possible combinations