has viral glycoproteins and host plasma membrane that binds to specific receptor molecules
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what does cell provide for virus in infection
Front
provides:
nucleotides
amino acids
enzymes
tRNA
host cell provides DNA polymerase but RNA viruses use viral RNA polymerase
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prion
Front
infections proteins
converts folded protein into misfolded protein and interferes with normal protein act
can cause degenerative brain diseases (mad cow)
acts slowly
indestructible with no known cures
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what do viruses not have/can't do
Front
lack machinery/structures found in cells
cannot reproduce outside host cell
cannot carry out metabolic activities on their own
only intracellular parasite
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Virus
Front
an infection particle consisting of genes packaged in a protein coat
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host range
Front
virus can only infect limited number of host species
"lock and key" -- between viral surface proteins and specific receptor molecules on outside of host cells
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infection
Front
begins when virus binds to host cell and viral genome enters the cell
viral proteins take over host and reprogram cell to copy viral nucleic acids and proteins
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bacteriophages
Front
viruses that infect bacteria
almost all have DNA genomes
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DNA/RNA in Virus
Front
contains either double-stranded or single stranded RNA or DNA
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parts of virus
Front
capsid: shell
genetic material: DNA/RNA
some have envelope: surround capsid, comes from membrane of host cell
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cell death from virus
Front
causes many symptoms associated with viral infections (cell breaks open from too many virus particles or cell is not able to make enough of its own proteins)
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retroviruses
Front
two identical ssRNA enter and used as template to form DNA using reverse transcriptase
viral dsDNA enters and is integrated in host DNA (called provirus)
provirus never leaves host DNA
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lytic cycle of virus
Front
results in host cell death (lytic = lysis, lysiss--breaks open) cell)
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reverse transcriptase
Front
creates complement to ssDNA
ssRNA->ssDNA->dsDNA
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simple replication
Front
copies nucleic acids and proteins
components self-assemble
hundreds/thousands of assembled viruses leave host cell (which could damage/destroy host cell)