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Birnaviridae

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Birnavirus causes what Dz

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6 years ago

Date created

Mar 1, 2020

Cards (17)

Section 1

(17 cards)

Birnavirus causes what Dz

Front

Infectious Bursal Dz (IBD) aka Gumboro Dz- affecting bursa of Fabricius

Back

CS of IBD

Front

distress, depression,ruffled feathers, diarrhea, anorexia, dehydration, swollen bursa with hemorrhages

Back

When is the highest susceptibility to IBDV

Front

between 3-6 weeks

Back

Structure of birnaviridae

Front

non enveloped viruses, hexagonal outline, single shell with icosahedrl symmerty, 2 segments of linear DS RNA (A and B)

Back

Bovine toroviruses is also known as

Front

breda virus which causes profuse diarrhea in young calves

Back

Timeline of changes to the bursa of fab

Front

enlarged edematous bura (acute), return to normal size but maybe hemorrhagic (5 days post infection), bursa atrophied to 1/8 of normal size (8 days post infection)

Back

Vaccines for IBDV

Front

Live vx from fully or partiallt attenuated strains of virus known as milk, intermediate or intermediate plute (hot)

Back

How does IBDV trigger a cytokine storm (Acute mortality)

Front

Indirectly via T cell activation and directly through macrophage activation

Back

Immune complex vaccines for IBDV

Front

live IBD vaccine virus + anti- IBDV antibody innoulated in egg (in ovo) at 18 days of incubation

Back

2 serotypes of IBDV

Front

type 1 for chickens have 3 antigenic subgroups, variant viruses (no mortality), classic or standard viruses (10-50% mortality) and very virulent viruses (50-100% mortality), and type 2 in turkeys and chickens is asymptomatic

Back

Who should receive inactivated vaccines for IBDV

Front

for layers and breeders

Back

Transmission of IBDV

Front

fecal oral, very stable in environment, survives disinfection, stays in water and feed after 52 days

Back

Pathogenesis of IBDV

Front

replication in Gut associated macrophages and lymphocytes in the ceca and SI, goes to liver the bloodstream, targets the bursa of fab (depleting B lymphocytes), causes secondary viremia and localization in other tissues, causes immunosupression

Back

Live recombinant vaccine for IBDV

Front

uses a viral vector (herpes virus of turkeys) to express VP2 antigen of IBDV in chickens- newly licenced

Back

Toroviruses

Front

named for donut shaped nucleocapsid, causes gastroenteritis in mammals (cows) via fecal oral

Back

Who should recive live vaccines for IBDV

Front

broilers and for initial vx and priming of breeders and layers pullets

Back

When can you vaccine chicks with the milk vaccine strains that cause no bursal lesions

Front

about 4 weeks old once the maternal derived antibodies have been neutralized

Back