Section 1
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CCB adverse effects
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Last updated
6 years ago
Date created
Mar 1, 2020
Cards (61)
Section 1
(50 cards)
CCB adverse effects
constipation reflex tachycardia peripheral edema Headache flushing gingival hyperplasia
role in therapy of selective BB
Heart failure post-MI
Who should we avoid using thiazide diuretics in?
sulfonamide allergy CrCl < 30 mL/min not with NSAIDs
adverse effects of lorcaserin
HA, N/V, dizziness, fatigue dry eye, constipation, xerostomia nasopharyngitis
how often would a clonidine patch be applied?
weekly
which of alpha-2 agonists are useful in pregnancy?
methyldopa
which CCB is first choice in pregnancy?
nifedipine ER
contraindications of lorcaserin
pregnancy/breastfeeding serotonin syndrome/neuroleptic malignant syndrome
ACE-inhibitors place in therapy
first line for hypertension (not in African Americans) HF high coronary disease risk DM CKD stroke
potassium sparing diuretics are safe to use in patients who have ______
gout
Place in therapy for thiazide diuretics?
1st line for African Americans
ARB's are basically interchangeable with ACE inhibitors, except they are different in what ways?
less cough and angioedema risk no washout period with Entresto
adverse effects of cilostazol
bleeding peripheral edema dizziness headache
which CCB should not be used in chronic HTN or for acute BP reduction?
nifedipine IR (leads to MI)
How is cilostazol taken (dosing, etc.)
100mg BID 30 minutes before or 2 hours after a meal
which of the CCB's are the safest?
amlodipine and felodipine
monitoring for lorcaserin
serotonin syndrome depression severe mood alterations/euphoria/dissociative state
what should also be taken with orlistat?
multivitamin with ADEK at bedtime or 2 hours after dose
CCB dihydropyridines role in therapy
First line in HTN
adverse effects of selective BB
Heart block hypotension/syncope dyspnea, bronchospasm decreased libido fatigue, dizziness, depression exercise intolerance
ACE inhibitors in PAD benefit
asymptomatic AND symptomatic CV risk reduction
What benefits do anti-platelet agents provide?
reduce overall CV morbidity but do not address symptoms
what benefits does cilostazol provide?
claudication symptoms increase in walking distance 90% relief in 5 years
what is unique about acebutolol?
it does not decrease HR like other selective BB and has ISA activity, so not recommended in post-MI
contraindications of orlistat
pregnancy/breastfeeding chronic malabsorption syndrome cholestasis oxalate nephrolithiasis
unique note for all CCB's?
CYP3A4 substrates = DDI (avoid grapefruit, lower statin dose)
When should we avoid using potassium sparing diuretics?
CrCl < 10 mL/min
adverse side effects of anti-platelet agents
bleeding
When are non-DHP CCB's used?
high coronary disease risk
risk with orlistat (limiting ADE)
> 30% kcal from fat meal results in greater GI side effects
unique risks of selective BB
abruptly D/C can cause rebound tachycardia (always taper) caution with HR < 60, asthma/COPD may mask signs of hypoglycemia and cause decrease in insulin secretion
adverse effects of alpha-2 agonists?
sedation hemolytic anemia dry mouth muscle weakness dizziness, constipation decrease HR
adverse effects of ACE-inhibitors
HYPERKALEMIA dry cough angioedema hypotension increase in SCr
place in therapy for potassium sparing diuretics
adverse effects of phentermine/topiramate ER
headache, paresthesia, insomnia, xerostomia, constipation, anxiety, depression, cognitive impairment, dizziness
ADE of non-DHP CCB's?
constipation peripheral edema headache flushing gingival hyperplasia heart block
side effects of orlistat
fecal urgency incontinence flatulence oily spotting abdominal pain
When do you avoid using cilostazol?
HF
When should ACE inhibitors be avoided?
pregnancy hypersensitivity to angioedema renal artery stenosis in solitary functional kidney potassium > 5.5
When should non-DHP CCB's be used cautiously?
when in combination with beta-blockers due to risk of heart block
What happens when alpha-2 agonists are discontinued abruptly?
rebound HTN
What is important to do when switching from an ACE-i to Entresto?
36 hour washout
what do you monitor for if on cilostazol?
S/S of bleeding
Statin place in therapy for PAD
high intensity indicated for all patients
Which of the CCB's is IV?
nicardipine
what needs to be monitored when on an anti-platelet agent?
S/S of bleeding
Which BB are selective (B1)
Acebutolol Atenolol Betaxolol Bisoprolol Esmolol Metoprolol
thiazide diuretic ADE
sexual dysfunction increase LDL, TG and BG decrease electrolytes (K, Na, Mg)
potassium sparing diuretics ADE
photosensitivity and rash hyperkalemia gynecomastia SJS, TEN impotence can enhance hyperkalemia
When are central alpha-2 agonists used?
hypertensive urgency
Section 2
(11 cards)