a small, nonprotein, water-soluble molecule or ion, such as a calcium ion (Ca2+) or cyclic AMP, that relays a signal to a cell's interior in response to a signaling molecule bound by a signal receptor protein
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g protein-coupled receptor
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a signal receptor protein in the plasma membrane that responds to the binding of a signaling molecule by activating a G protein
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protein kinase
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an enzyme that transfers phosphate groups from ATP to a protein, thus phosphorylating the protein
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hormonal signaling
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specialized endocrine cells secrete hormones into body fluids, often the blood
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protein phosphatases
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an enzyme that removes phosphate groups from (dephosphorylates) proteins, often functioning to reverse the effect of a protein kinase
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ligand
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a signal molecule that binds specifically to another molecule, usually a larger one
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cell-cell recognition
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two cells in an animal may communicate by interaction between molecules protruding from their surfaces
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ligand-gated ion channel
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receptor tyrosine kinases
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a receptor protein in the plasma membrane, the intracellular part of which can catalyze the transfer of a phosphate group from ATP to a tyrosine on another protein
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intracellular receptor
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hormones
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in multicellular organisms, one of many types of secreted chemicals that are formed in specialized cells, travel in body fluids, and act on specific target cells in other parts of the body to change their functioning
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apoptosis
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a program of controlled cell suicide, which is brought about by signals that trigger the activation of a cascade of suicide proteins in the cell destined to die
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response
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paracrine signaling
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(local) a secreting cell acts on nearby target cells by discharging molecules of a local regulator
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transduction
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reception
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cell junctions
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allows molecules to pass readily between adjacent cells
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synaptic signaling
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(local) a nerve cell releases neurotransmitter molecules into a synapse, stimulating the target cell
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signal transduction pathway
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a series of steps linking a mechanical or chemical stimulus to a specific cellular response
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phosphorylation cascade
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adenylyl cyclase
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an enzyme that converts ATP to cyclic AMP in response to a signal