Be familiar with table H11-1: Antioxidants and chronic disease risk and which antioxidants decrease risks of disease.
Front
1. Vitamin C - coronary heart disease, breast cancer, colorectal cancer, GI cancer, LUNG CANCER
2. Vitamin E - PROSTATE CANCER
3. Beta-carotene: chd, lc, crc, pc, gic, lc, pc
4. Carotenoids: lc, crc, pc
5. Fruits/veggies - chd, bc, crc, gic,
Back
What physical properties of vitamin C enable it to work as an antioxidant?
Front
-can donate 1-2 electrons to stabilize free radicals
-protects tissues from oxidative stress
-loses electrons easily
Back
What are the symptoms and effects of scurvy?
Front
-gums bleed easily around the teeth
-capillaries under the skin break spontaneously
-muscles degenerate
-skin becomes rough and scaly
-fractures in bones develop
-scar tissue does not form
-anemia/infections
-hysteria/depression
-sudden death: massive internal bleeding
Back
Explain how antioxidants help protect our body from the damages of free radical.
Front
-copper, selenium, manganese, zinc (donate 1-2 electrons to free radicals, thus decreasing their productivity)
-Vitamin E: defends body lipids
-Beta-carotene: defends lipid membranes
-Vitamin C: protects skin and blood fluid
Back
What are some factors that can lead to free radicals production in the body?
Describe how free radicals affect the body in 3 ways and what they can lead to.
Front
1. Cell damage
2. Disease progression
3. Aging
-attack polyunsaturated fatty acids, turn them into lipid radicals
-attack DNA/RNA, resulting in altered DNA/RNA, thus resulting in the absence or excess of specific proteins
-attack proteins, alter them, impair cell function/inflammatory response
*sometimes helpful in immune responses
Back
Know the prescribed dietary strategies for preventing heart disease.
Front
-use unsaturated fats instead of saturated
-select foods rich in omega-3 fatty acids
-high consumption of fruits, vegetables, nuts, whole grains (low consumption of redefined grain products)
-supplements not recommended; may INCREASE risk (usually no benefit)
Back
What is a free radical? Antioxidant?
Front
Free Radical: compound with one or more unpaired electron; predisposed to steal electron from vulnerable compound
Antioxidant: neutralize free radicals; defend body against oxidative stress
Back
What are some of the effects of oxidative stress?
Front
-reduced cognitive performance
-cancer and heart disease
-arthritis and cataracts
-diabetes
-impacts body's natural defenses/repair systems