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Pathology

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What is defective in Xeroderma Pigmentosum?

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Pathology

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Last updated

6 years ago

Date created

Mar 1, 2020

Cards (42)

Section 1

(42 cards)

What is defective in Xeroderma Pigmentosum?

Front

nucleotide excision repair

Back

What are myelin figures?

Front

Aggregates of damaged cell membranes seen in necrosis

Back

What cancer is caused by vinyl chloride?

Front

Angiosarcoma

Back

What are promoters?

Front

Chemicals that promote proliferation and growth, but do not affect the DNA.

Back

What is the main cell recruited in acute inflammation?

Front

Neutrophils

Back

Which leads to an inflammatory response, Apoptosis or Necrosis?

Front

Necrosis

Back

What is TNM staging?

Front

size of Tumor, Node involvement, Metastases

Back

fat necrosis

Front

Back

Where does lung and breast cancer metastasize to?

Front

The brain

Back

What are the BRCA genes responsible for?

Front

DNA repair

Back

Benzene is associated with what cancer?

Front

Leukemia

Back

liquefactive necrosis

Front

Bacterial and fungal causes

Back

What hormone causes cachexia, fever, and inflammation.

Front

TNF- alpha

Back

What is the gene product of BCR-ABL?

Front

Tyrosine kinase

Back

What cancer is caused by radon?

Front

Lung cancer

Back

Gangrenous necrosis (dry gangrene)

Front

Back

caseous necrosis

Front

white and cheesy appearance

Back

What are initiators?

Front

Chemicals that lead to irreversible damage to a cell's DNA.

Back

Aflatoxins are associated with what type of cancer?

Front

Liver cancer

Back

What hormone causes Cushing syndrome?

Front

Adrenocorticotropic hormone

Back

Translocation of what chromosomes cause Burkitt's lymphoma?

Front

14 and 18

Back

What is the gene product of HER2?

Front

Tyrosine Kinase

Back

What type of tumor is associated with the N-myc gene?

Front

Neuroblastoma

Back

What is Lambert-Eaton Myasthenic Syndrome?

Front

Autoimmune disorder caused by abs directed toward presynaptic calcium channels in the neuromuscular jxn

Back

What tumor is associated with p53?

Front

Li-Fraumeni

Back

What is the main source of nitrosamines?

Front

smoked foods

Back

Fibrinoid necrosis

Front

seen in the walls of blood vessels

Back

Asbestos is associated with what type of cancer?

Front

Mesothelioma

Back

Alkylating agents are associated with what type of cancer?

Front

Leukemia

Back

What is the main cell involved in chronic inflammation?

Front

Macrophages

Back

Ionizing radiation is associated with what type of cancer?

Front

Papillary thyroid carcinoma

Back

What type of tumor is associated with c-myc?

Front

Burkitt lymphoma

Back

Coagulative necrosis (red infarct)

Front

Back

What type of tumor is associated with the BRAF gene?

Front

non-Hodgkin lymphoma

Back

What is the gene product of BCL-2?

Front

Antiapoptotic molecule

Back

Arsenic is associated with what type of cancer?

Front

Squamous cell carcinoma of the skin

Back

What is Tumor grade?

Front

The degree of cellular differentiation and mitotic activity

Back

Where does colon cancer metastasize to?

Front

Liver

Back

What chromosome is BCR-ABL located on?

Front

9, 22 - Philadelphia chromosome

Back

Coagulative necrosis (white infarct)

Front

Back

Gangrenous necrosis (wet necrosis)

Front

Back

Where do prostate and breast cancer metastasize to?

Front

The bone

Back