name two AEDs which are rarely-used because of their irreversible side effects
Front
vigabatrin (permanent loss of vision)
felbamate (lethal hepatic failure)
Back
side effects of phenytoin
Front
-hirsutism (growth of excess unwanted body hair)
-coarsened facial features
-gingival hyperplasia (gums grow over and cover up your teeth)
Back
AEDs can produce
Front
irreversible side effects
Back
side effects of valproate
Front
-weight gain
-metabolic syndrome
-hair loss
-easy bruising
Back
CNS side effects usually are
Front
dose-related and reversible
Back
CNS side effects are
Front
very common with AEDs
Back
newer AEDs are more often
Front
enzyme-inhibitors
Back
4 reasons why DDIs with AEDs are especially problematic
Front
1. AEDs are used chronically
2. AEDs are often used with other types of drugs
3. AEDs are often used together
4. AEDs are increasingly used for other indications