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AP Biology - Chapter 19

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Section 1

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Reproductive Cycle of Lipid Enveloped RNA Virus

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Biology Science

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Mar 1, 2020

Cards (23)

Section 1

(23 cards)

Reproductive Cycle of Lipid Enveloped RNA Virus

Front

1. glycoproteins on viral envelope bind to specific receptor molecules on host cell, promoting viral entry into cell 2. capsid and viral genome enter cell-digestion of capsid by cellular enzymes releases viral genome 3. viral genome functions as template for synthesis of complementary RNA strands by viral envelope 4. new copies of viral genome RNA made using complementary RNA strands as templates 5. complementary RNA strands also function as mRNA, translated into capsid proteins (in cytosol) and glycoproteins for viral envelope (ER, Golgi) 6. vesicles transport envelope glycoproteins to plasma membrane 7. capsid assembles around each viral genome molecule 8. each new virus buds from cell, envelope studded w/ viral glycoproteins embedded in membrane derived from host cell

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Prophage

Front

phage DNA incorporated w/ bacterial DNA

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Vaccine

Front

harmless variant of pathogen that stimulates immune system to mount defenses against harmful purposes

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Reverse Transcriptase

Front

enzyme that transcribes RNA template to DNA

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Lytic Cycle

Front

-phage reproductive cycle that culminates in death of host cell 1. Attachment: page uses tail fibers to bind to specific receptor sites on surface bacteria 2. Entry of phage DNA and degradation of host DNA: sheath of tail contracts, injecting the phage DNA into cell and leaving empty capsid outside -> cells DNA hydrolyzed 3. Synthesis of viral genomes and proteins: phage DNA directs production of phage proteins and copies of phage genome w/ host enzymes 4. Assembly: 3 separate sets of proteins self-assemble to form phage heads, tails, and tail fibers; genome packaged in capsid as head forms 5. Release: phage directs production of enzyme that damages bacterial cell wall -> fluid enters -> cell swells and bursts, releasing 100-200 phage particles

Back

Virulent Phage

Front

phage that reproduces only by lytic cycle

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Viral Envelopes

Front

-membranous envelope surrounding capsids of many animal viruses -derived from membranes of host cells -contain host cell phospholipids and membrane proteins -contain viral proteins and glycoproteins

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Bacteriophage (Phage)

Front

-viruses that infect bacteria -capsids w/ elongated icosahedral heads w/ DNA -protein tail piece w/ fibers by which phages attach to bacterium attached to head

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Epidemic

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huge outbreak of disease

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Prion

Front

-infection proteins that cause many degenerative brain diseases of many animals -mostly transmitted w/ food-incubation 10+ years -virtually indestructible propagate by: -misfolded versions of normal brain proteins -contact w/ normal folded protein -> normal gets abnormal shape -chain rxn of misfolding -> cellular malfunction, brain degeneration

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HIV Reproductive Cycle

Front

1. envelope glycoproteins enable virus to bind to specific receptors on certain white blood cells 2. virus fuses w/ cell's plasma membrane-capsid proteins removed, releasing viral proteins and RNA 3. reverse transcriptase catalyzes synthesis of DNA strand complementary to viral RNA 4. reverse transcriptase catalyzes synthesis of second DNA strand complementary to first 5. double stranded DNA incorporated as provirus -> permanent resident of cell 6. proviral genes transcribed into RNA molecules-serves as genomes for next viral generation and as mRNAs for translation into viral protein 7. viral proteins include capsid proteins, reverse transcriptase, and envelope glycoproteins 8. vesicles transport glycoproteins to cell's plasma membrane 9. capsids assemble around viral genomes and reverse transcriptase molecules 10. new viruses bud off host cells

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Temperate Phage

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phage capable of using both modes of reproduction in bacteria

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HIV

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-Human Immunodeficiency Virus -retrovirus causing AIDS

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Viral Reproduction

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1. virus binds to host cell and enters uncoated, releasing viral DNA and capsid proteins 2. viral genome encodes proteins to have host reprogram cell to copy viral nucleic acid and replicate viral genome 3. meanwhile, host enzymes transcribe viral genome into viral mRNA, which host ribosomes use to make more capsid proteins 4. viral genomes and capsid proteins self-assemble into new virus particles, which exit cell to infect other cells and spread viral infection

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Virus

Front

-smaller and simpler than eukaryotes -technically nonliving b/c cannot reproduce/carry out metabolic activity outside host cell

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Pandemic

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global epidemic

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Retrovirus (Class VI)

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-RNA animal virus w/ most complex reproductive cycles -have reverse transcriptase enzyme

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Viroid

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-circular RNA molecules that infect plants -replicate in host plant cells using host enzymes instead of encoding proteins -cause errors in regulatory system that control plant growth -> stunted growth, abnormal development

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Host Range

Front

limited variety of host cells each type of virus can affect

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Emerging Viruses

Front

viruses that are new to medical scientists/suddenly appear b/c: 1. mutation of existing viruses -> new strains of disease -> epidemics 2. dissemination of viral disease from small, isolated human population-can be due to technological and social factors (radiation, travel, blood transfusion, sexual promiscuity, drugs, etc...) 3. spread of existing virus from other animals

Back

Capsid

Front

-protein shell enclosing viral genome -built from capsomere protein subunits -usually have few types of proteins making up capsid

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Lysogenic Cycle

Front

phage reproductive cycle w/ replication of phage genome w/o destroying host 1. phage DNA incorporated on site of bacterial chromosome -> prophage 2. bacterium reproduces normally, copying prophage and transmitting it to daughter cells 3. many cell divisions -> large population of infected bacteria

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AIDS

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Acquired Immunodeficiency Syndrome

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