Section 1
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Main points for Paget's:
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Last updated
6 years ago
Date created
Mar 1, 2020
Cards (93)
Section 1
(50 cards)
Main points for Paget's:
Increased osteoclast activity results in increased, unorganized osteoblast activity Enlarged, but weakened bones Delayed diagnosis due to slow progression of disease Musculoskeletal, neurologic, and cardiovascual symptoms Can be treated and reversed with medication
Are men or women more likely to be affected with Paget's?
Men
How can Paget's be diagnosed?
Delayed diagnosis Alkaline Phosphate Test Bone Scan Radiographs
Osteoporotic bones can be called:
Soft bones due to loss of structural integrity
What are the primary types of osteoporosis?
Postmenopausal Age-related
What areas have a higher incidence of Paget's?
Usually in locations of British migration i.e. US, Canada, Australia, New Zealand
What are some causes of osteoporosis?
Hormonal disturbance Disuse Senility Lack of exercise Poor diet Family history
What are some musculoskeletal symptoms of Paget's?
Bone pain, weakness, skeletal deformities
Can you correct osteoporosis?
Can't be completely reversed or corrected Goal is to slow down progression
When does Paget's occur?
Rarely before 35 years of age 3-4% of 50+ years 10% of 70+ years Declining prevalence and severity since 1983
Where are there low incidences of Pott's, who does it affect, and what part of the body does it affect?
Countries with low TB prevalence i.e. US More common in adults emigrating from endemic, immuno-compromised areas Targets Lumbar vertebrae
Paget's Disease:
Progressive skeletal disorder Bone remodeling disorder in one or multiple bones of the skeleton Elevated bone resorption Excessive, unorganized bone formation
How can osteoporosis be seen clinically?
Back pain Fractures Kyphosis Significant bone loss prior to diagnosis
Activation bone remodeling phase:
Osteoclasts stimulated Remove localized packets of bone
What pharmacotherapy can be used with Paget's?
Bone resorption inhibitors Induce long-lasting remission into eventual complete remission
How can osteoporosis be managed?
Diet Physical Activity Daylight Exposure Orthotic and Orthopaedic Devices Hormonal Supplements Pharmaceuticals
Reversal bone remodeling phase:
Osteoclast action stops Osteoblast action simulated Osteoblast migrate to excavation site
What can be causes (etiology) of Paget's?
Genetic Viral
Paget's Disease effect on bone remodeling cycle:
High rate of bone turnover Accelerated formation of structurally unstable bone (Enlarged bone, but weakened)
What type of Orthotic devices can you use for treatment of Osteoporosis?
What disease does Wolff's Law apply to?
Osteoporosis
Which is higher and which is lower in osteoporosis? (resorption/formation)
Bone resorption is greater Bone formation is lesser
How can osteoporosis be treated with pharmaceuticals?
Bone Resorption Inhibitors Bone Formation Stimulators
How can Paget's be seen in a clinical setting?
Insidious, slow progression Varied presentation Symptom-free initially, then onset Sustained, minimal symptoms
Osteoporosis:
Skeletal disorder involving global (not localized) parts of the skeleton Osteopenia is a common precursor
What are the treatment options for osteoporosis?
Medication Calcium Vitamin C & D Exercise Early estrogen replacement Oscillation Plate Therapy
What are the clinical symptoms of Pott's disease?
Tuberculosis Infection Degeneration single or multiple vertebrae (necrosis of intervertebral disc) Spinal cord compression Collapse of vertebral bodies (flat like a pancake)
What is the Sclerotic phase of Paget's?
Increased, unorganized osteoblast activity Thickened trabecular and cortical bone Chaotic, woven "mosaic" pattern
Where are there high incidences of Pott's, who does it affect, and what part of the body does it affect?
Countries with high TB prevalence Common in children Targets thoracic vertebrae
What are some cardiovascular symptoms of Paget's?
Decreased blood flow to brain Vasodilation of blood vessels
How can you diagnose osteoporosis?
Medical History Bone Mineral Density Testing X-Ray
Pott's disease can also be called?
Spinal tuberculosis
What animal does a paget's disease bone scan resemble?
Monkey
Resorption bone remodeling phase:
Mineral and organic bone components removed Micro-trench excavated from bone surface
Main points for Osteoporosis:
Bone resorption is greater than bone formation, resulting in low bone density and high risk for fractures Two types of primary: postemenopausal (type 1) and age-related (type 2) Secondary is associated with other conditions, diseases, or medications Increase peak bone mass to help slow progression/prevent onset
What are the secondary types of osteoporosis?
Life-style activities Smoking, alcohol, nutrition Medication Underlying Disease
What treatments can be used with Paget's?
Pain management Exercise Surgery Orthotic Care
What part of the bone does Paget's effect?
Entire part of bone Cancellous and cortical??
What are some risk factors of osteoporosis?
Age Hormonal status Hereditary/Genetic Ethnicity Physical Inactivity Alcohol Smoking Medication Depression Diet and Nutrition
Osteoclast:
Bone-resorption cell
What is the Lytic phase of Paget's?
Increased osteocalst activity Flame/wedge shaped
What are some neurological symptoms of Paget's?
Nerve impingement Lack of blood to neural tissue
What are some symptoms of Paget's?
Musculoskeletal Neurological Cardiovascular Fatigue Loss of appetite Hypercalcemia
What are the risk factors of Pott's?
Immune deficiency Chronically ill (i.e. HIV/AIDS) Antimicrobial resistance Drug and alcohol addiction Developing countries/Immigrants
What is a gibbus deformity and what disease is it associated with?
Kyphotic skeletal curve Pott's disease
What can Paget's disease also be called?
Osteitis Deformans Osteodystrophia Deformans
Osteblast:
Bone-forming cell
What type of Orthotic devices can you use for treatment of Paget's Disease?
What part of the bone does osteoporosis affect?
Primarily involves cancellous trabecular bone
What are the 4 phases of the bone remodeling process?
Activation Resorption Reversal Formation
Section 2
(43 cards)