b. fetal red blood cells enter the maternal circulation during birth and initiate an immune response that may endanger a future fetus
Front
Which of the following occurs in hemolytic anemia of the newborn?
a. maternal red blood cells cross enter the fetus during birth and initiate an immune response in the newborn
b. fetal red blood cells enter the maternal circulation during birth and initiate an immune response that may endanger a future fetus
c. the Rh+ mother attacks the Rh- fetus
d. the Rh- mother becomes sensitized to her own blood
Back
d. active hyperemia
Front
In weight lifting, muscles undergo _________.
a. passive hyperemia
b. reactive hyperemia
c. thromboembolism
d. active hyperemia
Back
d cri du chat
Front
Which of the following diseases results from a deletion of part of the chromosome 5?
a. down syndrome
b. turners syndrome
c. edwards syndrome
d. cri du chat
Back
c. mosaicism
Front
The least common form of the down syndrome is the _______ type.
a. sex-linked
b. complete triplication 21st chromosome
c. mosaicism
d. translocation
Back
a. he shows all of the main traits that define the disease
Front
An individual is a heterozygote for an autosomal dominant disorder. You predict that ______.
a. he shows all of the main traits that define the disease.
b.he shows only half of the traits that define the disease.
c. he does not show any of the traits that define the disease
d. there is no way to make a prediction unless one knows the genotype of his spouse
Back
b. familial hypercholesterolemia
Front
Which of the following is a co-dominant disorder?
a. phenylketonuria
b. familial hypercholesterolemia
c. achondroplasia
d. ochronosis
Back
b. spina bifida occulta
Front
Which of the following congenital malformations is an example of dysraphic defect?
a. hypoplasia
b. spina bifida occulta
c. syndactyly
d. arachnodactyly
Back
c. neurofibromatosis
Front
Which of the following diseases results in numerous benign tumors that affect the peripheral nerves?
a. wallerian degeneration
b. polyneuritis
c. neurofibromatosis
d. polyarteritis nodosum
Back
a. turners syndrome
Front
pterygium colli occurs in _____.
a. turner's syndrome
b. klinefelters syndrome
c. multi-x females
d. virilism
Back
c. congenital lack of B or T lymphocytes
Front
Which of the following circumstances results in a primary immunodeficiency?
a. malnutrition
b. diabetes mellitus
c. congenital lack of B or T lymphocytes
d. exposure to radiation
Back
c. marfan's syndrome
Front
A very tall caucasian basketball player dies from an aortic aneurysm. Which of the following is the most reasonable explanation?
a. syphilis
b. congenital malformation
c. marfan's syndrome
d. neurofibromatosis
Back
a. an autosomal recessive
Front
Genetic mutations that lead to enzyme defects usually inherit in _______ pattern.
a. an autosomal recessive
b. an autosomal dominant
c. a sex-linked
d. a hemizygous
Back
a. consanguinity (in-breeding)
Front
The Amish people of Pennsylvania suffer from more genetic disease than the population of the United States in general. This is due to _________.
a. consanguinity (in-breeding)
b. some local environmental problem, probably food contamination
c. their descent from a very genetically diverse groups of original settlers
d. their devout religion
Back
b. maternal ingestion of alcohol during the pregnancy
Front
Which of the following is a well-known risk factor for a congenital malformation?
a. an unusually small uterus
b. maternal ingestion of alcohol during the pregnancy
c. twins
d. taking aspirin during the third trimester
Back
a. bone cancer
Front
Which of the following tumors is most likely to metastasize through the circulation system?
a. bone cancer
b. breast carcinoma
c. brain tumor
d. Hodgekin's lymphoma
Back
b and inactive chromosome
Front
A barr body is ________.
a. one of the polar bodies produced in female gametogenesis
b. an inactive chromosome
c. a viral inclusion in a sperm cell
d.composed of euchromatin
Back
b. Marfan's syndrome
Front
Arachnodactyly, or "spider fingers," is seen in _________.
a. Ehlers-Danlos syndrome
b. Marfan's syndrome
c. Wilson's disease
d. thalidomide consumption during pregnancy
Back
a. type I
Front
The primary problem lies in abnormal vascular function in _________hypersensitivity.
a. type I
b. type II
c. type III
d. type IV
Back
a. trisomy 21
Front
Which of the following conditions is most compatible to life?
a. trisomy 21
b. monosomy 21
c. trisomy 17
d. cri du chat syndrome
Back
a. diabetes
Front
Which of the following circumstances results in a secondary immunodeficiency?
a. diabetes
b. the Down syndrome
c. tuberculin test
d. thymic aplasia
Back
d. alcaptonuria (ochronosis)
Front
In which of the following conditions does the cartilage turn blue-black?
a. lead poisoning
b. wilson's disease
c. addison's disease
d. alcaptonuria (ochronosis)
Back
b. achondroplasia (dwarfism)
Front
which of the following is an autosomal dominant condition?
a. hemophilia
b. achondroplasia (dwarfism)
c. albinism
d. gaucher's disease
Back
d. greater than for siblings who are not twins
Front
If one member of a pair of fraternal (non-identical) twins is born with a congenital defect, the probability that the other member will have the same defect is _________.
a. 100%
b. the same as if they were identical twins
c. 50%
d. greater than for siblings who are not twins
Back
b. homocystinuria
Front
All of the following clinical signs and symptoms occur in marfan's syndrome with the exception of one. Which does not occur?
a. tendency of the lens of the eye to subluxate (upward)
b. homocystinuria
c. dissecting aneurysm of the aorta
d. arachnodactyly (spider fingers)
Back
c. they only have one X chromosome
Front
Males tend to phenotypically express sex-linked conditions because ________.
a. they sustain more mutations on their X chromosomes
b. they are all genetic hybrids
c. they only have one X chromosome
d. they have an extra barr boy
Back
a. A new mutation has occurred during parental gametogenesis
Front
A male child is born with marfan's syndrome, even though neither of the parents expressed this condition. What is the most likely explanation?
a. a new mutation has occurred during parental gametogenesis
b. this disease is a sex-linked disorder
c. this disease is an autosomal recessive disorder
d. this disease is an autosomal dominant disorder
Back
c. they are inborn errors of metabolism
Front
Which one of the following characteristics is true of lysosomal storage diseases?
a. they are lethal at any age.
b. they are involved an inability to store fat.
c. they are inborn errors of metabolism
d. the victim is invariably obese
Back
b. mast cells
Front
In type I hypersensitivity, antigen-antibody complex causes the degranulation of __________.
a. eosinophils
b. mast cells
c. T cells
d. B cells
Back
c. the interaction of several genes
Front
In the case of polygenic (aka multifactorial) defects __________ is the primary cause of the disorder.
a. a single gene defect
b. a chromosomal problem
c. the interaction of several genes
d. teratogens
Back
a. there are self reactive antibodies
Front
Autoimmunity refers to the process in which ________.
a. there are self reactive antibodies
b. the body learns to identify foreign proteins
c. the body tolerates its own proteins
d. a person injects himself with immunosuppressive drugs
Back
c. 45, XO
Front
Which of the following is the karyotype for turner's syndrome?
a. 46, XY-), (47, XXY)
b. 47, XXY
c. 45, XO
d 45, YO
Back
c. type III
Front
Immune complex deposition occurs in __________ hypersensitivity.
a. type I
b. type II
c. type III
d. type IV
Back
b. cause unknown
Front
About 70% of congenital birth defects are due to _______.
a. genetic causes
b. cause unknown
c. biochemical defects
d. maternal infection
Back
c. hypovolemic
Front
Dehydration results in __________ shock.
a. septic
b. cardiogenic
c. hypovolemic
d. anaphylactic
Back
a. an autosomal dominant disorder
Front
A patient has a genetically defective collagen. This genetic disorder is ________.
a. an autosomal dominant disorder
b. an autosomal recessive disorder
c. a sex-linked
d. acquired during childhood from an affected play-mate
Back
c. pedunculated
Front
Which of the following terms refers to a tumor that is shaped like a mushroom?
a. sessile
b. dermoid
c. pedunculated
d. polyp
Back
b. the heart
Front
The likely source of an embolism that occludes the renal artery is ________.
a. the kidney
b. the heart
c. lower extremity veins
d. lower extremity arteries
Back
c. syndactyly
Front
Which of the following congenital malformations is and example of a division failure?
a. hypoplasia
b. spina bifida occulta
c. syndactyly
d. arachnodactyly
Back
d. delayed onset
Front
A positive tuberculin test is an example of __________ hypersensitivity.
a. immediate-onset
b. cell-mediated
c. cytotoxic
d. delayed onset
Back
a. B cells
Front
In Bruton's disease, the victim has a congenital lack of functional __________.
a. B cells
b. T cells
c. B and T cells
d. one of his or her 21st chromosomes
Back
a. monosomy or trisomy
Front
abnormal meiosis may result in ______.
a. monosomy or trisomy
b. only trisomy
c. only monosomy
d. polar bodies
Back
Rheumatoid arthritis
Ankylosis spondylitis
Crohn's disease
Multiple sclerosis
Myasthenia gravis
Hashimotos
Type I diabetes
Front
List some autoimmune diseases.
Back
d. vitamin D resistant rickets
Front
which of the following is a sex-linked dominant condition?
a. lesch-nyhan syndrome
b. amaurotic familial idiocy
c. gastrophilia
d. vitamin D resistant rickets
Back
b. has a 1/2 chance of expressing the disorder
Front
A male homozygote and a female heterozygote for an autosomal dominant disorder produce a child. This child ___________.
a. cannot possibly express the disorder
b. has a 1/2 chance of expressing the disorder
c. has a 1/4 chance of expressing the disorder
d. must show the disorder.
Back
a. pregnant mammals were not tested
Front
What went wrong with thalidomide testing is that _________.
a. pregnant mammals were not tested
b. the experimental dosage was not controlled
c. the experimental time of exposure was not controlled
d. not all human research subjects provided informed consent.
Back
c. Ehlers-Danlos syndrome
Front
Increased elasticity of the skin occurs in _________.
a. neurofibromatosis
b. ankylosing spondylitis
c. Ehlers-Danlos syndrome
d. Sclerodema