1) Any digit between the first nonzero digit on the left and the last nonzero digit on the right is significant.
2) Any zeros to the left of the first nonzero digit are considered to be leading zeros and are not significant.
3) If there are zeros to the right of the last nonzero digit and there is a decimal point in the number, than those zeros are significant figures. If there is no decimal point, then they are not
4) For measurements, the last digit is usually an estimation and is not considered significant